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Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

For recovery and performance, consistent use over 1224 weeks provides the best results

Retest at 90 days Draw again to measure any changes

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Risk-of-bias reduction strategies such as robust randomization methods, allocation concealment, blinding of outcome assessors, and intention-to-treat analysis should be incorporated to improve internal validity and reproducibility