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10.1016/j.biochi.2020.04.019 130 RoseS.MelnykS.SavenkaA.HubanksA.ClevesS

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The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14