A., Mantella, R
doi: 10.1007/s40265-019-01192-z 46 DuftonNHannonRBrancaleoneVDalliJPatelHBGrayMet al
therefore, prescribers usually restrict use to adults unless compelling justification exists
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DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45