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A 2017 paper in the Journal of Molecular Medicine documented receptor activation and upregulation in vascular endothelium (PMID 27847966)

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Of interest, GLO1 inhibitors have been shown to reverse the sensitivity of tamoxifen-resistant breast cancer cells, revealing that GLO1 may be a biomarker for predicting the efficacy of endocrine therapies and a target for overcoming treatment resistance (158)

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