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(2024) Aging Cell , PMC10776128 Confirmed that NAD+ metabolism interfaces with multiple biological hallmarks of ageing including cellular senescence, genomic instability, mitochondrial dysfunction, and altered intercellular communication

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In humans, kavain undergoes extensive hepatic metabolism, primarily via cytochrome P450 (CYP) enzyme-mediated pathways, followed by further phase II biotransformation processes such as sulfonation, glucuronidation, and glutathione (GSH) conjugation

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