It enrolled adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity, and randomized them across multiple retatrutide dose arms (1 mg, 4 mg, 8 mg, and 12 mg weekly) versus placebo
Interestingly, individuals with low levels of GIP may also have low levels of GLP-1 and vice versa (49)

Plus I feel 20 years younger. Indirect Costs Lost work productivity: Obesity-related health issues cause more sick days and reduced performance Reduced career opportunities: Studies show weight bias affects hiring and promotions Clothing costs: Plus-size clothing often costs more, and frequent size changes from yo-yo dieting add up Quality of life: Priceless, but consider what youre missingplaying with your kids, traveling comfortably, feeling confident, enjoying activities you love Future Healthcare Costs Obesity significantly increases your lifetime healthcare spending: Obese individuals spend $1,400-$2,500 more per year on medical care than healthy-weight individuals The cumulative cost over 20-30 years can exceed $30,000-$75,000 This doesnt account for catastrophic events like heart attacks, strokes, or cancerall more common in obese populations Investing $3,000-$4,000 in a year-long medical weight loss program could save you tens of thousands in future medical costs

Phase 2 MRI-PDFF data showed a 22.2% absolute reduction in liver fat fraction at the 12 mg dose [2]
GLP-1 addressable market