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The highest doses of medications like tirzepatide have shown even more impressive results, with some patients losing up to twenty-two percent of their initial weight

However, some healthcare providers may consider prescribing both medications together off-label in select patients who have not achieved adequate weight loss with monotherapy

CCM measures parameters including corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fiber length (CNFL), all of which are significantly reduced in patients with subclinical and clinical DPN compared with controls