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A deficiency can be caused either by diseases that increase the need for glutathione, or by nutrient deficiencies required for synthesis, but also by diseases that inhibit its formation.Additionally, smoking increases the use rate of glutathione, both in the detoxification of nicotine and in the neutralization of free radicals produced by tobacco smoke

Thus, the peroxidase-like activity of CuS NPs favors OH formation to eliminate senescent chondrocytes

10.1016/j.biomaterials.2011.05.008 59 LiF.LiW.LiX.LiF.ZhangL.WangB.et al (2016a)