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Any suspicious pigmentary lesion with irregular or asymmetric margins or those that are ulcerated, exophytic, or heterogeneous should be excised and assessed to exclude melanoma[78,92]

Further evidence for this hypothesis comes from recent yeast two-hybrid studies performed with enzymes from sweet peony, where the arGST Ps GSTF3 was found to interact with Ps DFR, the dihydroflavonol reductase catalysing the formation of 3,4- cis -leucocyanidin ( 6 ) 47