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The accumulation of altered key tumor suppressor genes such as TP53 and CDKN2A, which encode p53 and p16INK4A, respectively is associated with the onset, progression and poor prognosis of HPV-negative HNSCC

Inflammatory factors, in addition to OS, play a significant role in the development of diabetes by promoting IR through the alteration of -cell function and interference with insulin signaling (Oguntibeju, 2019)

All authors have read and agreed to the published version of the manuscript. Ethical Approval: Our institution does not require ethical approval for reporting individual cases or case series

His concerns were appropriately received by Empower and were considered and addressed. That case is ongoing