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J Orthop Surg Res 14, 199 (2019)

Natural compounds in epigenetics: a current view

Conversely, CHAC1 deficiency in tumor cells results in resistance to CTL-mediated cytotoxicity and impairs the efficacy of checkpoint blockade therapies, highlighting its pivotal role in mediating the success of immunotherapy (Xue et al., 2023)

Importantly, since GSH can be regulated systemically in humans by dietary supplementation, our data raises the possibility of a simple and safe intervention to prevent NK cell dysfunction in patients treated with seclidemstat