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Dimeric macrocycles induce Met activated cellular phenotypes The activation of Met signalling induces unique biological responses such as proliferation 23,24 , migration 23,25 and morphogenesis 22,26

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The four healthy bile samples were pooled to serve as a normalization reference, which enabled robust quantification of polyp versus gallstone differences but precluded direct assessment of disease-specific versus shared alterations relative to healthy baseline

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Targeted treatment of ischemic stroke by bioactive nanoparticle-derived reactive oxygen species responsive and inflammation-resolving nanotherapies