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For patients with genetic predispositions to reduced GLP-1 sensitivity, GLP-Squared Injectiona dual compound combining semaglutide and tirzepatideaddresses multiple hunger pathways simultaneously

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OA-induced GLP-1 release was significantly inhibited by incubation of cells with U73122 or with the Ca 2+ chelator, BAPTA-AM (78 6 and 82 5% inhibition, respectively), but not with myristoylated PKI (14 8% inhibition) (Figure 5A)

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