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Sources alimentaires de purines [PDF document]

And factors like stress, sleep disruption, and medication interactions can all blunt the appetite-suppressing effect temporarily

Interestingly, OCT3 is associated with metformin uptake and efflux in the salivary glands, which may account for the dysgeusia associated with metformin treatment [22]

Patients may experience diminished appetite suppression, slower weight loss, or loss of glycemic control if using these medications for diabetes management

While this delayed emptying is exactly what helps you feel full longer and consume fewer calories, it is also the primary driver behind most GLP 1 gastrointestinal side effects