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It is currently being studied as a combination therapy with GLP-1 receptor agonists , such as semaglutide and retatrutide, showing synergistic effects in weight management trials

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MMPs also have a role in reorganization of TJ proteins claudin-5 and occludin, leading to disruption of TJ adhesion, augmented by IL-1 and TNF circulation as well as oxidative stress (Yang et al., 2007

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