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(79) showed that promoting CB proliferation and SCFA production repairs the colonic mucosal barrier in DSS-induced mice by upregulating tight-junction proteins and increasing goblet cell numbers, dependent on CB -mediated amino acid and 2-oxocarboxylic acid metabolism

Management strategies are largely extrapolated from experience with existing GLP-1 receptor agonists, such as semaglutide and liraglutide, which are licensed and available in the UK

trial showed IV glutathione achieved 37.5% response versus 18.7% placebo, with benefits fading completely by 6 months

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