The translocation barrier height, G , is calculated by averaging and subtracting the value of the two lowest free energy minima ( G A and G C in Fig
Modern pharmacokinetics has underscored the importance of a loading dose to achieve circulating values above bacterial Minimal Inhibitory Concentrations (MIC) to reduce the risk of resistance 6,7
The ABR wave-I amplitude, which represents cochlear nerve activity, can provide an objective measure of cochlear synaptopathy when cochlear thresholds and associated hair cell function remain normal 16 , while the wave V, generated in the lateral lemniscus and inferior colliculus 44 , is commonly used to evaluate central auditory gain
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