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Proton magnetic resonance spectroscopy ( 1 H MRS), with its extremely high sensitivity, is used for detecting and quantifying several endogenous tissue metabolites in a single acquisition, but it is not capable of tracking the activity of a metabolic pathway due to limitations related to water, lipid suppression, and magnetic field homogeneity [22]

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Second, NADPH is required for inhibiting lipid oxidation and serves as an indicator of ferroptosis in various types of tumor cells (Wang et al., 2023)

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