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Short answer, the one that matters: no meaningful human signal, the thyroid black box is a rodent-dose precaution (the same way the old estrogen black box was more politics than data), and we actually see lower rates of some cancers in people taking them
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Market Barriers and Challenges Despite the strong growth outlook, the obesity therapeutics sector continues to face substantial challenges
When alcohol was again made available after the up-titration period, the semaglutide-treated animals drank significantly less alcohol relative to vehicle [F (1, 18) = 9.939, P = 0.0055], with a significant effect of week [F (2,709, 48,76) = 6.441, P = 0.0013] and treatment by week interaction [F (3, 54) = 5.207, P = 0.0031] (Fig