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8 Relevant factors can include: The substance and its known pharmacological properties Express or implied health claims The intended route of use Packaging and labelling Website imagery and product categories Testimonials and social-media content Instructions supplied with the product Describing a material as a supplement, peptide or research product does not determine its legal classification by itself

Peer review Peer review information Nature Communications thanks Nicolas Rouhier and Mirko Zaffagnini for their contribution to the peer review of this work

25,399,400,401,402,403 Targeting peptides Nonspecific cell binding is the leading cause of the off-target effects observed with several therapeutic molecules

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The identification of the plant specimens was authenticated by the Department of Botany, Government College for Women, Thiruvananthapuram (Fig