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PMCID: PMC9512238

3.8.3 Glyphosate Glyphosate is a widely used herbicide acting via inhibition of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase, which blocks the shikimate pathway responsible for synthesizing aromatic amino acids including phenylalanine, tyrosine and tryptophan (Chiantia et al., 2025)

Despite unchanged ILC2 numbers, melatonin significantly reduced BALF IL-5 and IL-13 levels ( Figures 1M, N ), suggesting functional suppression of type 2 cytokine production rather than depletion of ILC2s ( Figures 1K, L )

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In addition to the intensive propidium iodide fluorescence of root cell nuclei indicating cell death in AITC-treated roots (Fig