The temporal association between starting semaglutide and developing joint symptoms may be coincidental rather than causal, highlighting the importance of thorough clinical evaluation
Science 387 , eadn3949 (2025)
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Safety considerations Available evidence suggests that combined therapy with SGLT2 inhibitors and GLP-1 receptor agonists is generally well tolerated, with safety profiles largely consistent with those of each class individually [24, 40,41,42,43]