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Patients should contact their healthcare provider if headaches are severe, persistent, or progressively worsening despite conservative management measures

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Studies have shown that JAK2 may also phosphorylate insulin receptor substrate 1/2 (IRS1/2) and activate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway (Ridderstrale et al., 1995

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PI3K pathway Oncogenic RAS, a participant in the MAPK pathway as discussed earlier, also functions as a positive regulator upstream of the PI3K pathway