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3.1.2 Role of Nrf2/HO-1 pathway in ferroptosis and antioxidant defense The Nrf2/heme oxygenase-1 (HO-1) pathway plays a central role in oxidative stress-induced ferroptosis

274 Interestingly, the predicted targets of the differentially expressed miRNAs were enriched with genes related to neurobiology, the cell cycle, and cell signalling and largely overlapped with genes previously identified via differential mRNA expression analysis of ASD patients

Abbreviations AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis AMPK: AMP-activated protein kinase BBB: Blood-brain barrier CNS: Central nerve system EAAT-1: Excitatory amino acid transporter 1 EAE: Experimental allergic encephalomyelitis H 2 O 2 : Hydrogen peroxide MCI: Mild cognitive impairment MS: Multiple sclerosis MSU: Monosodium urate mTOR: Mammalian target of rapamycin NO: Nitric oxide ONOO : Peroxynitrite PD: Parkinsons disease RNS: Reactive nitrogen species ROS: Reactive oxygen species SCI: Spinal cord injury SOD: Superoxide dismutase TFEB: Transcription factor EB TLR: Toll-like receptor UA: Uric acid VEGF: Vascular endothelial growth factor XO: Xanthine oxidase References Burtscher J, Millet GP, Place N, Kayser B, Zanou N

doi: 10.1371/journal.pone.0032214

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