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Dysfunction of the SDH-b subunit begins with a significant increase in intracellular succinate concentration Kluckova and Tennant (2018)

89 There is no generally accepted medical therapy to treat PSC, so therapeutic efforts are directed toward complications of the disease

There are specific clinical reasons behind this combination

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If there is not enough evidence to rule out potential confounds or other factors that could impact this outcome of having a diagnosis of autism, then we simply can't, in good practice, implement a guideline. In the statement issued by the Food and Drug Administration on the changes, it also notes a missing causal relationship