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doi: 10.1056/NEJMoa1515920 7 NealBPerkovicVMahaffeyKWde ZeeuwDFulcherGEronduNet al

( A ) Mouse caSMCs were transfected with a combination of 4 MTP-specific siRNAs, and relative Mtpa mRNA expression was measured by reverse transcription PCR versus control siRNA

This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients