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Retrospective case series of paediatric patients referred to national poisons centres also report a lower rate of liver injury and hepatotoxicity in children compared with adults following single acute overdose [52,53,54,55]

It becomes very important to produce CoQ 10 in body due to following reasons:- Oxidative stress Age related changes Insufficient dietary CoQ 10 intake Zinc: It is a mineral associated with normal functioning of male reproductive system

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Publications from PubMed and Web of Science that met the selection criteria but lacked corresponding registry numbers were also retained to ensure a comprehensive overview of DHT applications in rare disease trials

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