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The pigmentation is active: as long as tobacco exposure continues, the melanocytes remain stimulated and pigment continues to deposit

Lastly, to evaluate the robustness of the associations detected, we additionally included data collected from NESDA subjects still available at 6-year follow-up by pooling all observations (N = 4141) in a unified mixed model with two random factors (one for the family effect and one for the repeated observations from the same subject over time)

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Sci Rep (2020) 10:1862