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SP is found presynaptically (Tamiya et al., 1990) and NK1R is expressed postsynaptically on dopaminergic neurons and other neuron subtypes in the VTA (Lessard and Pickel, 2005)

[1] [2] These effects can reduce fluid intake and cause fluid losses, which may lead to dehydration and reduced urine output rather than increased urination

When someone on tirzepatide is eating significantly less food , dietary carnitine intake naturally drops alongside overall caloric intake, making supplementation potentially more relevant

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Aim for adequate water intake throughout the day, especially when starting a new supplement routine