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Blood, buffy coat and fecal sampling Plasma and buffy coat sampling Blood samples were collected in the fasting state and 1, 2, 4, 6, 9, 12 and 24 h after the beef meal as breakfast on the test day

In adults without type 2 diabetes, orforglipron 36mg demonstrated a comparable cardiometabolic profile to oral semaglutide 25mg (CEI 0.67 vs

The FTO rs9939609 variant also affects baseline appetite set-point regulation and can influence how aggressively semaglutide reshapes food preferences

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