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These metabolites exert metabolic-epigenetic feedback to the nucleus, modulating the activities of epigenetic enzymes, including DNA methyltransferases (DNMTs), TET enzymes, histone acetyltransferases (HATs), and deacetylases (HDACs/SIRTs)

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It is one of the most actively researched peptides in published preclinical literature, frequently cited in models exploring tissue repair signalling, gastrointestinal mucosal protection, tendon and ligament research, and angiogenic pathway behaviour

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