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10.1038/onc.2017.38 140 ZhouL.QuH.YangL.ShouL

doi:10.1136/bmj-2023-076410 4

Metformin Use with GLP-1 RA: Synergy Towards Better Outcomes Metformin with GLP-RA Effect on Weight-Lowering Response: A 52-week prospective study including 194 obese T2D patients showed concomitant initiation of metformin alongside GLP-1 receptor agonist therapy is associated with enhanced weight loss efficacy, suggesting a potential synergistic metabolic interaction that improves the likelihood of achieving clinically meaningful weight reduction

In the outcome of changes in the ALT levels, moderate credibility of ICEMAN result shows that L-carnitine supplementation has no difference in changes in younger ones (MD: 0.4, 95%CI: 1.32 to 2.12) but has significant changes (reduced) in adults (MD: 31.7, 95%CI: 47.61 to 15.79)

Improvement in sperm chromatin quality was demonstrated by oral intake of some anti-oxidant agents such as LC (10)