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Tirzepatide is a prescription medication, meaning access to it requires a healthcare providers approval

Most people notice metabolic changes within 4-8 weeks, with visible reductions in abdominal fat appearing around 3-6 months of consistent use

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Orforglipron also surpassed oral semaglutide in terms of weight loss: 36-milligram doses of Eli Lillys drug resulted in an average of 8 percent body-weight reduction (nearly 20 pounds) compared with 5 percent weight loss (11 pounds) in participants who took 14 mg of oral semaglutide