NDA filing is expected in Q4 2026 at the earliest, with an FDA decision realistic in 2027 or later
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It is not known if Ozempic will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people Do not use Ozempic if: you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) you have had a serious allergic reaction to semaglutide or any of the ingredients in Ozempic Before using Ozempic , tell your health care provider if you have any other medical conditions, including if you: have or have had problems with your pancreas have a history of vision problems related to your diabetes have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation) are pregnant or breastfeeding or plan to become pregnant or breastfeed
They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain
