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Furthermore, it was shown that curcumin has been found to significantly reduce H3ac levels in the IL-6 promoter as well as IL-6 mRNA expression in RA synovial fibroblasts (RASFs) (Makuch et al., 2021

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Arisaka O, Hoshi M, Kanazawa S, Nakajima D, Numata M, Nishikura K, Oyama M, Nitta A, Kuribayashi T, Kano K, Nakayama Y, Yamashiro Y (2001) Systemic effects of transdermal testosterone for the treatment of microphallus in children