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In contrast, in models with GLS mutations, glutamate metabolism in tumor cells is restricted, which increases Gln concentration in the microenvironment and T-cell uptake and antitumor activity

Liposomes protective effect has been attributed to their amphiphilic structure, which facilitates interaction with the skins lipid bilayer and improves the transport and release of antioxidants directly into affected cells [62]

FBXO22 and other ubiquitination machinery are already known to play a vital role in this pathway, and the reactivity of cysteines is frequently altered 13,34,35

PMID 29037268