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Operational Workflow & Compliance Checks Consistent execution of this protocol relies on clearly defined operational workflows and accountability (Table 3)

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This PK-PD disconnect is compatible with a peptide whose mechanism triggers downstream signalling cascades (VEGFR2 activation, fibroblast migration, angiogenesis) that persist well beyond direct peptide presence

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Group sizes were determined on the basis of previously established n numbers required to demonstrate the size of the effect expected from the in vitro results, without formal power calculations