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A maximal deletion of Gclc was required to cause weight loss and reduction in survival in mice, as heterozygous deletion did not cause mice to lose weight (Fig

Statements Author contributions MB: Conceptualization, Formal analysis, Funding acquisition, Methodology, Visualization, Writing original draft, Writing review & editing

Although many of the actions of sulphonylureas and glinides are therefore attributable to the actions of endogenous insulin, additional actions may also be mediated by direct effects on skeletal muscle K ATP channels

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