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The findings could lead to new blood tests to diagnose the nature and severity of depression

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Given that YAP is a transcriptional co-activator known to translocate into the nucleus in response to ECM stiffening in various cell types, including melanoma cells (Miskolczi et al, 2018), and that YAP may serve as a potential MITF partner in uveal melanoma cells (Barbosa et al, 2023), we wondered whether YAP could be associated with the observed ECM-dependent MC phenotypes

Nicotinamide mononucleotide (NMN), an NAD + supplement, also activates PGC-1 [173, 174]