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Acting as second messengers in the insulin cascade, IPGs facilitate glucose uptake, glycogen synthesis, and lipid metabolism through the activation of key enzymes such as pyruvate dehydrogenase and glycogen synthase (135)

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The successful development of glucagon-like peptide-1 (GLP-1) receptor agonists, followed by the synergistic combined effect of glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists achieved remarkable weight loss and glycemic control in those with the diseases of obesity and type 2 diabetes