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Its mechanisms include: Nitric oxide modulation regulates blood flow and inflammation at injury sites Growth factor upregulation increases EGF, FGF, and VEGF expression Gut-brain axis signaling systemic effects mediated through the GI tract Dopaminergic system interaction neuroprotective properties BPC-157 is unique among healing peptides because it works systemically through the gut , even when administered locally

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Moreover, the elevated GSH levels in intestinal tissues observed following metformin treatment may originate from the gut microbiota, as indicated by the upregulation of the GshF gene