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People do report weight loss on compounded semaglutide, but that observation sits outside the evidence base, because compounded preparations are not studied in randomised trials and the FDA does not verify their safety, effectiveness or quality before marketing

Marked poikilocytosis is also noted with the presence of distorted red blood cells, irregularly contracted red blood cells, and red blood cells with apparently uneven distribution of the hemoglobin inside them (hemighosts)

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K23 DK116720-01), in addition to research support by Juvenile Diabetes Research Foundation (JDRF), NIDDK/DiaComp, NIDDK/KPMP, Thrasher Research Fund, International Society of Pediatric and Adolescent Diabetes (ISPAD), Colorado Clinical & Translational Sciences Institute (CCTSI) and Center for Womens Health Research at University of Colorado

Instead, the observed shedding appears tied to the rate and magnitude of weight loss rather than the medication's pharmacology