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coli , and plants share a common three-dimensional fold (Hibi et al., Figure 3 The best-studied GCL are those from non-plant eukaryotes and consist of a catalytic heavy subunit (M r ~70 kDa) and a regulatory light subunit (M r ~30 kDa

If possible, the combination of interacting drugs should be avoided

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Sometimes, maintaining a lower dose for a longer period before escalating, or even reducing the dose temporarily, can improve tolerability whilst still providing therapeutic benefit

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