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Rigorous, adequately powered randomised controlled trials, with standardised background therapy, longitudinal biomarker sampling, and patient-reported outcomes, are now needed to determine efficacy, optimal candidates, and durability of response

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Key highlights Tirzepatide (the active ingredient in brand names Zepbound and Mounjaro) is a dual receptor agonist of the GLP-1 and GIP receptors that promotes weight loss and blood sugar control when used alongside lifestyle changes

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