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Ray et al

The full GI side effect spectrum Based on the meta-analysis data, here is how the major GI side effects compare across dose levels

This formed the basis for Black's development of the first beta-blocker, propranolol, at Imperial Chemical Industries, a chemical conglomerate with pharmaceutical laboratories in Cheshire that he joined in 1958 and stayed with until 1964 when he moved to Smith Kline and French, an American pharmaceutical company with laboratories in Hertfordshire, South East England