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[PUBMED Abstract] McMeniman EK, Duffy DL, Jagirdar K, et al.: The interplay of sun damage and genetic risk in Australian multiple and single primary melanoma cases and controls

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For type 2 diabetes , NICE guideline NG28 recommends GLP-1 receptor agonists in specific circumstances, including: As part of triple therapy (with metformin and either a sulfonylurea or pioglitazone) when dual therapy with metformin and another oral drug has not achieved adequate glycaemic control As part of triple therapy with metformin and a sodium-glucose cotransporter 2 (SGLT2) inhibitor if certain criteria are met In combination with insulin, with or without other antidiabetic drugs Treatment should be continued only if there is a beneficial metabolic response (reduction of at least 11 mmol/mol in HbA1c and weight loss of at least 3% at 6 months)

Achieving and maintaining a healthy weight can be instrumental in controlling blood sugar in women with type-2 diabetes

Beyond weight loss: the cardiometabolic picture OASIS 4 is arguably as interesting for what it did to cardiometabolic risk as for the weight figures themselves, and this is the part worth bringing to colleagues who still file these drugs under cosmetic