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The following section extends this integrative perspective to neuroendocrine and immunemetabolic peptide systems, where complexity has similarly constrained translation despite compelling biological rationale

Our evidences suggested that impaired mitophagy may be a cause of cardiac hypertrophy induced by pressure overload, and semaglutide ameliorated the cardiac hypertrophy by improving mitophagy to suppress the activation of NLRP3 inflammasome (Fig

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