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Thorax 57(10):875879 Hamid Q, Tulic MK, Liu MC, Moqbel R (2003) Inflammatory cells in asthma: mechanisms and implications for therapy

The freezing process can drive freeze-concentration, where the acid and peptide separate into pockets that concentrate the acid and can damage the peptide structure during thawing

Thiamine (Vitamin B1) helps maintain normal energy metabolism, and is critical to maintenance of normal muscle and nerve function