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But, how often depends on how bad the deficiency is and how well theyre doing

The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo

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Also, patients should be warned about the danger of taking folic acid in place of vitamin B 12, because the former may prevent anemia but allow progression of subacute combined degeneration

This approach mirrors dosing strategies used for other peptides with 1216 hour half-lives, though published 5-amino-1mq pharmacokinetic data in humans remains limited