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470 In this study, researchers randomized 529 patients with heart failure with a preserved ejection fraction and body mass index (weight in kilograms in the square of the height in meters) 30 to receive once-weekly injections of semaglutide (2.4 mg) or placebo for 52 weeks

[78] A 2024 systematic review found that tirzepatide demonstrates benefits in the management of metabolic dysfunctionassociated steatotic liver disease

Some people may lose a few pounds in the first week due to a reduced appetite or smaller portion sizes

The above cardiac and extracardiac effects outline the cardioprotective mechanisms of SGLT2 inhibitors that stay behind the success of these drugs in the cardiovascular field

Differential expression was calculated using limma v